Assay Detail
Binding
CHEMBL2014374
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Inhibition of aromatase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1399 | ANASTROZOLE | 4.0 | 1 | 7.92 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.82 |
| CHEMBL131921 | BIOCHANIN | — | 1 | - |
| CHEMBL2011191 | — | — | 1 | - |
| CHEMBL2011192 | — | — | 1 | - |
| CHEMBL2011193 | — | — | 1 | - |
| CHEMBL274826 | ANDROSTENEDIONE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1399 | ANASTROZOLE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL117 | CHRYSIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL131921 | BIOCHANIN | IC50 | = | 113000.0 | nM | - |
| CHEMBL2011191 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL2011192 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL2011193 | — | IC50 | >= | 200000.0 | nM | - |
| CHEMBL274826 | ANDROSTENEDIONE | IC50 | >= | 260.0 | nM | - |