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Assay Detail

CHEMBL2014385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli DNA gyrase B using relaxed pNO1 as substrate after 30 mins by fluorimetry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B.
Brvar M, Perdih A, Hodnik V, Renko M, Anderluh G, Jerala R, Solmajer T.
Bioorg Med Chem (2012) 20 : 2572 -2580
PubMed 22444877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.39 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36506 NOVOBIOCIN 4.0 1 7.82
CHEMBL2011391 1 4.19
CHEMBL2011390 1 4.16
CHEMBL2011210 1 -
CHEMBL2011211 1 -
CHEMBL2011212 1 -
CHEMBL2011392 1 -
CHEMBL2011393 1 -
CHEMBL2011394 1 -
CHEMBL2011395 1 -
CHEMBL2011396 1 -
CHEMBL2011397 1 -
CHEMBL2011398 1 -
CHEMBL2011399 1 -
CHEMBL2011400 1 -
CHEMBL2011401 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36506 NOVOBIOCIN IC50 = 15.0 nM 7.82
CHEMBL2011391 IC50 = 64000.0 nM 4.19
CHEMBL2011390 IC50 = 70000.0 nM 4.16
CHEMBL2011210 IC50 > 1000000.0 nM -
CHEMBL2011211 IC50 = 204000.0 nM -
CHEMBL2011212 IC50 = 680000.0 nM -
CHEMBL2011392 IC50 > 1000000.0 nM -
CHEMBL2011393 IC50 > 1000000.0 nM -
CHEMBL2011394 IC50 > 1000000.0 nM -
CHEMBL2011395 IC50 > 1000000.0 nM -
CHEMBL2011396 IC50 > 1000000.0 nM -
CHEMBL2011397 IC50 > 1000000.0 nM -
CHEMBL2011398 IC50 > 1000000.0 nM -
CHEMBL2011399 IC50 > 1000000.0 nM -
CHEMBL2011400 IC50 > 1000000.0 nM -
CHEMBL2011401 IC50 > 1000000.0 nM -