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Assay Detail

CHEMBL2014386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Escherichia coli N-terminal 24 kDa fragment of DNA gyrase B by surface plasmon resonance analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B.
Brvar M, Perdih A, Hodnik V, Renko M, Anderluh G, Jerala R, Solmajer T.
Bioorg Med Chem (2012) 20 : 2572 -2580
PubMed 22444877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 4.21 4.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2011391 1 4.21
CHEMBL2011210 1 -
CHEMBL2011211 1 -
CHEMBL2011212 1 -
CHEMBL2011390 1 -
CHEMBL2011392 1 -
CHEMBL2011393 1 -
CHEMBL2011394 1 -
CHEMBL2011395 1 -
CHEMBL2011396 1 -
CHEMBL2011397 1 -
CHEMBL2011398 1 -
CHEMBL2011399 1 -
CHEMBL2011400 1 -
CHEMBL2011401 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2011391 Kd = 62000.0 nM 4.21
CHEMBL2011210 Kd - -
CHEMBL2011211 Kd - -
CHEMBL2011212 Kd - -
CHEMBL2011390 Kd = 104000.0 nM -
CHEMBL2011392 Kd - -
CHEMBL2011393 Kd - -
CHEMBL2011394 Kd - -
CHEMBL2011395 Kd - -
CHEMBL2011396 Kd - -
CHEMBL2011397 Kd - -
CHEMBL2011398 Kd - -
CHEMBL2011399 Kd - -
CHEMBL2011400 Kd - -
CHEMBL2011401 Kd - -