Assay Detail
Binding
CHEMBL2014495
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Inhibition of GST-tagged Human papillomavirus 16 protein E6 interaction with His-tagged human caspase 8 expressed in Escherichia coli after 1 hr incubation followed by overnight incubation by Alpha screening technique
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human papillomavirus type 16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 6.07 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | — | 1 | 6.07 |
| CHEMBL28626 | MORIN | — | 1 | 5.40 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 2 | - |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL28626 | MORIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL150 | KAEMPFEROL | Inhibition | - | % | - | |
| CHEMBL50 | QUERCETIN | IC50 | > | 20000.0 | nM | - |
| CHEMBL150 | KAEMPFEROL | IC50 | > | 20000.0 | nM | - |