Assay Detail
Binding
CHEMBL2014639
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Binding affinity to BACE1 by NMR-based differential chemical shift perturbation method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fragment based drug discovery: practical implementation based on ¹⁹F NMR spectroscopy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 3.39 | 3.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011278 | — | — | 1 | 3.70 |
| CHEMBL2011271 | — | — | 1 | 3.46 |
| CHEMBL1981917 | — | — | 1 | 3.40 |
| CHEMBL185917 | — | — | 1 | 3.00 |
| CHEMBL2011272 | — | — | 1 | - |
| CHEMBL2011273 | — | — | 1 | - |
| CHEMBL2011279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011278 | — | Kd | = | 200000.0 | nM | 3.70 |
| CHEMBL2011271 | — | Kd | = | 350000.0 | nM | 3.46 |
| CHEMBL1981917 | — | Kd | = | 400000.0 | nM | 3.40 |
| CHEMBL185917 | — | Kd | = | 1000000.0 | nM | 3.00 |
| CHEMBL2011272 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL2011273 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL2011279 | — | Kd | > | 1000000.0 | nM | - |