Assay Detail
Binding
CHEMBL2014776
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Inhibition of Plasmodium falciparum DHODH after 20 mins by 2,6-dichloroindophenol-reduction based assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.95 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012961 | — | — | 1 | 7.77 |
| CHEMBL2012965 | — | — | 1 | 7.72 |
| CHEMBL2012955 | — | — | 1 | 7.68 |
| CHEMBL2012957 | — | — | 1 | 7.68 |
| CHEMBL1234899 | — | — | 1 | 7.66 |
| CHEMBL2012962 | — | — | 1 | 7.60 |
| CHEMBL2012952 | — | — | 1 | 7.55 |
| CHEMBL2012948 | — | — | 1 | 7.55 |
| CHEMBL2012960 | — | — | 1 | 7.50 |
| CHEMBL2012953 | — | — | 1 | 7.47 |
| CHEMBL2012963 | — | — | 1 | 7.46 |
| CHEMBL2012943 | — | — | 1 | 7.41 |
| CHEMBL2012958 | — | — | 1 | 7.40 |
| CHEMBL2012951 | — | — | 1 | 7.36 |
| CHEMBL2012956 | — | — | 1 | 7.31 |
| CHEMBL2012947 | — | — | 1 | 7.28 |
| CHEMBL2012944 | — | — | 1 | 7.25 |
| CHEMBL2012945 | — | — | 1 | 7.25 |
| CHEMBL2012824 | — | — | 1 | 7.22 |
| CHEMBL2012966 | — | — | 1 | 7.21 |
| CHEMBL2012829 | — | — | 1 | 7.10 |
| CHEMBL2012949 | — | — | 1 | 7.04 |
| CHEMBL2012964 | — | — | 1 | 7.02 |
| CHEMBL2012830 | — | — | 1 | 6.96 |
| CHEMBL2012954 | — | — | 1 | 6.96 |
| CHEMBL2012821 | — | — | 1 | 6.85 |
| CHEMBL2012950 | — | — | 1 | 6.79 |
| CHEMBL2012831 | — | — | 1 | 6.75 |
| CHEMBL2012959 | — | — | 1 | 6.74 |
| CHEMBL2012825 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012961 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2012965 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2012957 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2012955 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1234899 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2012962 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2012952 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2012948 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2012960 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2012953 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2012963 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2012943 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2012958 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2012951 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2012956 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2012947 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2012944 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2012945 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2012824 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2012966 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2012829 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2012949 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2012964 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2012830 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2012954 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL2012821 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2012950 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2012831 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2012959 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL2012825 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2012941 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2012946 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL2012823 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2012822 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2012820 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL2012827 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL2012942 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2012826 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL2012819 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012828 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012940 | — | IC50 | > | 30000.0 | nM | - |