Assay Detail
Binding
CHEMBL2014777
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Inhibition of human DHODH after 20 mins by 2,6-dichloroindophenol-reduction based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.05 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012961 | — | — | 1 | 5.51 |
| CHEMBL2012963 | — | — | 1 | 5.25 |
| CHEMBL2012964 | — | — | 1 | 5.14 |
| CHEMBL2012966 | — | — | 1 | 4.83 |
| CHEMBL2012831 | — | — | 1 | 4.82 |
| CHEMBL2012965 | — | — | 1 | 4.76 |
| CHEMBL2012821 | — | — | 1 | - |
| CHEMBL2012822 | — | — | 1 | - |
| CHEMBL2012823 | — | — | 1 | - |
| CHEMBL2012824 | — | — | 1 | - |
| CHEMBL2012825 | — | — | 1 | - |
| CHEMBL2012826 | — | — | 1 | - |
| CHEMBL2012827 | — | — | 1 | - |
| CHEMBL2012829 | — | — | 1 | - |
| CHEMBL2012820 | — | — | 1 | - |
| CHEMBL2012941 | — | — | 1 | - |
| CHEMBL2012951 | — | — | 1 | - |
| CHEMBL2012962 | — | — | 1 | - |
| CHEMBL2012830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012961 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2012963 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2012964 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2012966 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL2012831 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL2012965 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL2012821 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012822 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012823 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012824 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012825 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012826 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012827 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012829 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012820 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012941 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012951 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012962 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012830 | — | IC50 | > | 30000.0 | nM | - |