Assay Detail
Functional
CHEMBL2014781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human renal proximal tubule cells after 72 hrs by SYBR green assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012961 | — | — | 1 | 8.40 |
| CHEMBL2012955 | — | — | 1 | 8.22 |
| CHEMBL2012953 | — | — | 1 | 8.22 |
| CHEMBL2012957 | — | — | 1 | 8.15 |
| CHEMBL2012966 | — | — | 1 | 8.10 |
| CHEMBL1234899 | — | — | 1 | 8.05 |
| CHEMBL2012958 | — | — | 1 | 8.00 |
| CHEMBL2012965 | — | — | 1 | 7.92 |
| CHEMBL2012962 | — | — | 1 | 7.89 |
| CHEMBL2012960 | — | — | 1 | 7.77 |
| CHEMBL2012963 | — | — | 1 | 7.75 |
| CHEMBL2012943 | — | — | 1 | 7.66 |
| CHEMBL2012951 | — | — | 1 | 7.58 |
| CHEMBL2012948 | — | — | 1 | 7.55 |
| CHEMBL2012947 | — | — | 1 | 7.28 |
| CHEMBL2012964 | — | — | 1 | 7.22 |
| CHEMBL2012945 | — | — | 1 | 7.13 |
| CHEMBL2012824 | — | — | 1 | 7.05 |
| CHEMBL2012949 | — | — | 1 | 7.02 |
| CHEMBL2012956 | — | — | 1 | 6.99 |
| CHEMBL2012950 | — | — | 1 | 6.96 |
| CHEMBL2012829 | — | — | 1 | 6.96 |
| CHEMBL2012952 | — | — | 1 | 6.95 |
| CHEMBL2012954 | — | — | 1 | 6.95 |
| CHEMBL2012944 | — | — | 1 | 6.89 |
| CHEMBL2012821 | — | — | 1 | 6.82 |
| CHEMBL2012959 | — | — | 1 | 6.80 |
| CHEMBL2012830 | — | — | 1 | 6.75 |
| CHEMBL2012946 | — | — | 1 | 6.54 |
| CHEMBL2012820 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012961 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2012955 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2012953 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2012957 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2012966 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1234899 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2012958 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012965 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2012962 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2012960 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2012963 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2012943 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2012951 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2012948 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2012947 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2012964 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2012945 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2012824 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2012949 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2012956 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2012950 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2012829 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2012952 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2012954 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2012944 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2012821 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2012959 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL2012830 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2012946 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2012820 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2012825 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2012831 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2012823 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2012822 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2012941 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL2012827 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2012826 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2012819 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2012942 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2012940 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2012828 | — | IC50 | > | 40000.0 | nM | - |