Assay Detail
Binding
CHEMBL2014814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.41 | 4.54 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012951 | — | — | 1 | 4.54 |
| CHEMBL2012958 | — | — | 1 | 4.28 |
| CHEMBL1234899 | — | — | 1 | - |
| CHEMBL2012950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012951 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL2012958 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1234899 | — | IC50 | < | 2800.0 | nM | - |
| CHEMBL2012950 | — | Inhibition | - | % | - |