Assay Detail
Functional
CHEMBL2014858
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Cytotoxicity against human HL-60(TB) cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60(TB) |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.35 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012925 | — | — | 1 | 6.70 |
| CHEMBL2012933 | — | — | 1 | 6.68 |
| CHEMBL2012930 | — | — | 1 | 6.60 |
| CHEMBL2012927 | — | — | 1 | 6.57 |
| CHEMBL2012926 | — | — | 1 | 6.54 |
| CHEMBL2012931 | — | — | 1 | 6.35 |
| CHEMBL2012934 | — | — | 1 | 5.69 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.69 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012925 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2012933 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2012930 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2012927 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2012926 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2012931 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2012934 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL185 | FLUOROURACIL | IC50 | > | 2512000.0 | nM | - |