Assay Detail
Functional
CHEMBL2014859
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Cytotoxicity against human K562 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dimeric 3,5-bis(benzylidene)-4-piperidones: a novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.24 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012926 | — | — | 1 | 7.30 |
| CHEMBL2012925 | — | — | 1 | 6.70 |
| CHEMBL2012933 | — | — | 1 | 6.68 |
| CHEMBL2012927 | — | — | 1 | 6.66 |
| CHEMBL2012930 | — | — | 1 | 6.52 |
| CHEMBL2012931 | — | — | 1 | 6.50 |
| CHEMBL2012934 | — | — | 1 | 5.81 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.62 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012926 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2012925 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2012933 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2012927 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2012930 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2012931 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2012934 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL852 | MELPHALAN | IC50 | = | 43700.0 | nM | 4.36 |