Assay Detail
Binding
CHEMBL2014883
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Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in HEK292 cells after 4 hrs by liquid scintillation counting
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK292 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.86 | 6.30 |
| EC50 | 2 | 5.67 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084615 | — | — | 2 | 6.30 |
| CHEMBL576234 | — | — | 1 | 5.55 |
| CHEMBL2012935 | — | — | 1 | 5.41 |
| CHEMBL2010825 | — | — | 1 | - |
| CHEMBL2012936 | — | — | 1 | - |
| CHEMBL2012937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084615 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1084615 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL576234 | — | EC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL2012935 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL2010825 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2012936 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2012937 | — | Ki | > | 10000.0 | nM | - |