Assay Detail
Functional
CHEMBL2014888
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Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.53 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012939 | — | — | 1 | 10.70 |
| CHEMBL2012938 | VIALININ A | — | 1 | 10.05 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.60 |
| CHEMBL2013070 | — | — | 1 | 9.49 |
| CHEMBL2013071 | — | — | 1 | 9.26 |
| CHEMBL2013072 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012939 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL2012938 | VIALININ A | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2013070 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL2013071 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL2013072 | — | IC50 | = | 8.15 | nM | 8.09 |