Assay Detail
Binding
CHEMBL2015306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.20 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012477 | — | — | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.61 |
| CHEMBL2012478 | — | — | 1 | 5.39 |
| CHEMBL2012472 | — | — | 1 | 5.22 |
| CHEMBL2012474 | — | — | 1 | 5.05 |
| CHEMBL2012469 | — | — | 1 | 5.04 |
| CHEMBL2012475 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012477 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL2012478 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL2012472 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL2012474 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL2012469 | — | IC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL2012475 | — | IC50 | = | 42120.0 | nM | 4.38 |