Assay Detail
Functional
CHEMBL2015308
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Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bcap37 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.93 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.27 |
| CHEMBL2012477 | — | — | 1 | 5.18 |
| CHEMBL2012472 | — | — | 1 | 5.17 |
| CHEMBL2012476 | — | — | 1 | 5.14 |
| CHEMBL2012474 | — | — | 1 | 5.07 |
| CHEMBL2012478 | — | — | 1 | 5.06 |
| CHEMBL2012471 | — | — | 1 | 4.97 |
| CHEMBL2012470 | — | — | 1 | 4.79 |
| CHEMBL2012469 | — | — | 1 | 4.73 |
| CHEMBL2012475 | — | — | 1 | 4.49 |
| CHEMBL2012473 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL2012477 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL2012472 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL2012476 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2012474 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL2012478 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL2012471 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2012470 | — | IC50 | = | 16330.0 | nM | 4.79 |
| CHEMBL2012469 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL2012475 | — | IC50 | = | 32310.0 | nM | 4.49 |
| CHEMBL2012473 | — | IC50 | = | 41050.0 | nM | 4.39 |