Assay Detail
Functional
CHEMBL2015309
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Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.05 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012474 | — | — | 1 | 5.49 |
| CHEMBL2012472 | — | — | 1 | 5.34 |
| CHEMBL2012477 | — | — | 1 | 5.33 |
| CHEMBL2012469 | — | — | 1 | 5.24 |
| CHEMBL2012476 | — | — | 1 | 5.22 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.15 |
| CHEMBL2012478 | — | — | 1 | 4.99 |
| CHEMBL2012470 | — | — | 1 | 4.95 |
| CHEMBL2012471 | — | — | 1 | 4.89 |
| CHEMBL2012475 | — | — | 1 | 4.51 |
| CHEMBL2012473 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012474 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL2012472 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2012477 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2012469 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL2012476 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL2012478 | — | IC50 | = | 10330.0 | nM | 4.99 |
| CHEMBL2012470 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL2012471 | — | IC50 | = | 12910.0 | nM | 4.89 |
| CHEMBL2012475 | — | IC50 | = | 30710.0 | nM | 4.51 |
| CHEMBL2012473 | — | IC50 | = | 39220.0 | nM | 4.41 |