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Assay Detail

CHEMBL2015384

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.
Reddy MV, Venkatapuram P, Mallireddigari MR, Pallela VR, Cosenza SC, Robell KA, Akula B, Hoffman BS, Reddy EP.
J Med Chem (2011) 54 : 6254 -6276
PubMed 21812421 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 6.23 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1771376 — — 1 8.60
CHEMBL1241855 RIGOSERTIB 3.0 1 8.12
CHEMBL2013113 — — 1 8.12
CHEMBL2012986 — — 1 8.00
CHEMBL2013119 RIGOSERTIB SODIUM 3.0 1 7.82
CHEMBL2013110 — — 1 7.82
CHEMBL2013114 — — 1 7.82
CHEMBL2013118 — — 1 7.82
CHEMBL1771387 — — 1 7.70
CHEMBL2012977 — — 1 7.60
CHEMBL2013002 — — 1 7.52
CHEMBL2012994 — — 1 7.52
CHEMBL1771378 — — 1 7.30
CHEMBL2013112 — — 1 7.12
CHEMBL2013115 — — 1 7.10
CHEMBL2012995 — — 1 7.00
CHEMBL2013006 — — 1 6.82
CHEMBL2013111 — — 1 6.82
CHEMBL2013004 — — 1 6.70
CHEMBL2012998 — — 1 6.70
CHEMBL2013005 — — 1 6.70
CHEMBL2013117 — — 1 6.70
CHEMBL2013000 — — 1 6.60
CHEMBL2012999 — — 1 6.60
CHEMBL2012978 — — 1 6.60
CHEMBL2013116 — — 1 6.60
CHEMBL2012979 — — 1 6.60
CHEMBL2012982 — — 1 6.52
CHEMBL2012972 — — 1 6.30
CHEMBL2012973 — — 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1771376 — IC50 = 2.5 nM 8.60
CHEMBL1241855 RIGOSERTIB IC50 = 7.5 nM 8.12
CHEMBL2013113 — IC50 = 7.5 nM 8.12
CHEMBL2012986 — IC50 = 10.0 nM 8.00
CHEMBL2013119 RIGOSERTIB SODIUM IC50 = 15.0 nM 7.82
CHEMBL2013110 — IC50 = 15.0 nM 7.82
CHEMBL2013114 — IC50 = 15.0 nM 7.82
CHEMBL2013118 — IC50 = 15.0 nM 7.82
CHEMBL1771387 — IC50 = 20.0 nM 7.70
CHEMBL2012977 — IC50 = 25.0 nM 7.60
CHEMBL2013002 — IC50 = 30.0 nM 7.52
CHEMBL2012994 — IC50 = 30.0 nM 7.52
CHEMBL1771378 — IC50 = 50.0 nM 7.30
CHEMBL2013112 — IC50 = 75.0 nM 7.12
CHEMBL2013115 — IC50 = 80.0 nM 7.10
CHEMBL2012995 — IC50 = 100.0 nM 7.00
CHEMBL2013006 — IC50 = 150.0 nM 6.82
CHEMBL2013111 — IC50 = 150.0 nM 6.82
CHEMBL2013004 — IC50 = 200.0 nM 6.70
CHEMBL2012998 — IC50 = 200.0 nM 6.70
CHEMBL2013005 — IC50 = 200.0 nM 6.70
CHEMBL2013117 — IC50 = 200.0 nM 6.70
CHEMBL2012979 — IC50 = 250.0 nM 6.60
CHEMBL2013116 — IC50 = 250.0 nM 6.60
CHEMBL2012999 — IC50 = 250.0 nM 6.60
CHEMBL2013000 — IC50 = 250.0 nM 6.60
CHEMBL2012978 — IC50 = 250.0 nM 6.60
CHEMBL2012982 — IC50 = 300.0 nM 6.52
CHEMBL2012972 — IC50 = 500.0 nM 6.30
CHEMBL2012973 — IC50 = 750.0 nM 6.12
CHEMBL2012974 — IC50 = 750.0 nM 6.12
CHEMBL2012985 — IC50 = 750.0 nM 6.12
CHEMBL2012990 — IC50 = 800.0 nM 6.10
CHEMBL2013001 — IC50 = 800.0 nM 6.10
CHEMBL2013003 — IC50 = 800.0 nM 6.10
CHEMBL2012997 — IC50 = 1000.0 nM 6.00
CHEMBL1771372 — IC50 = 2500.0 nM 5.60
CHEMBL2012970 — IC50 = 2500.0 nM 5.60
CHEMBL2012987 — IC50 = 2500.0 nM 5.60
CHEMBL2012989 — IC50 = 2500.0 nM 5.60
CHEMBL2013007 — IC50 = 3000.0 nM 5.52
CHEMBL2012992 — IC50 = 5000.0 nM 5.30
CHEMBL2013008 — IC50 = 5000.0 nM 5.30
CHEMBL2012981 — IC50 = 5000.0 nM 5.30
CHEMBL2012980 — IC50 = 7500.0 nM 5.12
CHEMBL2012968 — IC50 = 7500.0 nM 5.12
CHEMBL2012993 — IC50 = 15000.0 nM 4.82
CHEMBL2012991 — IC50 = 15000.0 nM 4.82
CHEMBL2012967 — IC50 = 20000.0 nM 4.70
CHEMBL2012983 — IC50 = 20000.0 nM 4.70