Assay Detail
Binding
CHEMBL2015461
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Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 5.2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216319 | — | — | 1 | 7.05 |
| CHEMBL3216774 | — | — | 1 | 6.19 |
| CHEMBL408500 | — | — | 1 | 6.18 |
| CHEMBL2012656 | — | — | 1 | 5.79 |
| CHEMBL3216992 | — | — | 1 | 4.27 |
| CHEMBL2012659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216319 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3216774 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL408500 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2012656 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3216992 | — | IC50 | = | 53400.0 | nM | 4.27 |
| CHEMBL2012659 | — | IC50 | = | 144000.0 | nM | - |