Assay Detail
Binding
CHEMBL2015462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.76 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216319 | — | — | 1 | 7.58 |
| CHEMBL3216774 | — | — | 1 | 6.77 |
| CHEMBL408500 | — | — | 1 | 6.52 |
| CHEMBL2012656 | — | — | 1 | 6.16 |
| CHEMBL2012659 | — | — | 1 | - |
| CHEMBL2012658 | — | — | 1 | - |
| CHEMBL3216992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216319 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3216774 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL408500 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2012656 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL2012659 | — | Ki | - | — | - | |
| CHEMBL2012658 | — | Ki | - | — | - | |
| CHEMBL3216992 | — | Ki | - | — | - |