Assay Detail
Binding
CHEMBL2015571
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Inhibition of human recombinant Trx1/TrxR assessed as reduction in number of free thiols from reduced insulin after 30 mins by insulin reduction assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.59 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010865 | — | — | 1 | 6.70 |
| CHEMBL2010864 | — | — | 1 | 6.40 |
| CHEMBL1255721 | METHYL BROMOMETHYL ACRYLATE | — | 1 | 6.36 |
| CHEMBL1974159 | — | — | 1 | 5.92 |
| CHEMBL2010863 | — | — | 1 | 5.62 |
| CHEMBL2010867 | — | — | 1 | 5.52 |
| CHEMBL2010866 | — | — | 1 | 5.48 |
| CHEMBL2010860 | — | — | 1 | 5.41 |
| CHEMBL2010861 | — | — | 1 | 5.05 |
| CHEMBL2010859 | — | — | 1 | 5.00 |
| CHEMBL406050 | PX-12 | 2.0 | 1 | 4.91 |
| CHEMBL2010858 | — | — | 1 | 4.65 |
| CHEMBL2010857 | — | — | 1 | - |
| CHEMBL2010854 | — | — | 1 | - |
| CHEMBL2010804 | — | — | 1 | - |
| CHEMBL2010855 | — | — | 1 | - |
| CHEMBL2010856 | — | — | 1 | - |
| CHEMBL2010862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010865 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2010864 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1255721 | METHYL BROMOMETHYL ACRYLATE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1974159 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2010863 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2010867 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2010866 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2010860 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2010861 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2010859 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL406050 | PX-12 | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2010858 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL2010857 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2010854 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2010804 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2010855 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2010856 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2010862 | — | IC50 | > | 50000.0 | nM | - |