Assay Detail
Functional
CHEMBL2015725
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Antiproliferative activity against human KB cells after 72 hrs by fluorescence method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rigid Analogues of Antimitotic Indolobenzazepinones: New Insights into Tubulin Binding via Molecular Modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011460 | — | — | 1 | 8.70 |
| CHEMBL529447 | — | — | 1 | 7.46 |
| CHEMBL2011458 | — | — | 1 | 6.05 |
| CHEMBL2011459 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011460 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL529447 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2011458 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2011459 | — | IC50 | = | 5000.0 | nM | 5.30 |