Assay Detail
Binding
CHEMBL2015744
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Binding affinity to human sst5 by in vitro receptor autoradiography assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.09 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442494 | — | — | 1 | 8.68 |
| CHEMBL2011463 | — | — | 1 | 7.28 |
| CHEMBL2011461 | — | — | 1 | 7.12 |
| CHEMBL311695 | SEGLITIDE | 2.0 | 1 | 7.09 |
| CHEMBL2011462 | — | — | 1 | 6.90 |
| CHEMBL2011466 | — | — | 1 | 6.86 |
| CHEMBL2011465 | — | — | 1 | 6.71 |
| CHEMBL2011464 | — | — | 1 | 6.61 |
| CHEMBL2011467 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442494 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2011463 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2011461 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL311695 | SEGLITIDE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2011462 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL2011466 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL2011465 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL2011464 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL2011467 | — | IC50 | = | 263.0 | nM | 6.58 |