Assay Detail
Binding
CHEMBL2015860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]granisetron from 5HT3 receptor in Wistar rat cortical membranes by liquid scintillation spectrometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 3A (CHEMBL2411) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bivalent Ligands for the Serotonin 5-HT3 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.37 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011470 | — | — | 1 | 8.57 |
| CHEMBL195241 | — | — | 1 | 8.25 |
| CHEMBL2011586 | — | — | 1 | 8.11 |
| CHEMBL2011588 | — | — | 1 | 7.82 |
| CHEMBL2011596 | — | — | 1 | 7.75 |
| CHEMBL2011591 | — | — | 1 | 7.58 |
| CHEMBL2011587 | — | — | 1 | 7.57 |
| CHEMBL2011469 | — | — | 1 | 7.55 |
| CHEMBL2011471 | — | — | 1 | 7.17 |
| CHEMBL2011590 | — | — | 1 | 7.16 |
| CHEMBL2011589 | — | — | 1 | 7.15 |
| CHEMBL2011600 | — | — | 1 | 7.15 |
| CHEMBL2011599 | — | — | 1 | 7.05 |
| CHEMBL2011593 | — | — | 1 | 6.97 |
| CHEMBL2011597 | — | — | 1 | 6.90 |
| CHEMBL2011598 | — | — | 1 | 6.88 |
| CHEMBL2011592 | — | — | 1 | 6.85 |
| CHEMBL2011594 | — | — | 1 | 6.81 |
| CHEMBL2011595 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011470 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL195241 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL2011586 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL2011588 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2011596 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2011591 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2011587 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2011469 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL2011471 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL2011590 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL2011589 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2011600 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2011599 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL2011593 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL2011597 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL2011598 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL2011592 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL2011594 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL2011595 | — | Ki | = | 178.0 | nM | 6.75 |