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Assay Detail

CHEMBL2015897

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MNK2 using 5-FAM-TATKSGSTTKNRFVV-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 2 hrs by IMAP assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Publication

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.
Xu J, Chen A, Go ML, Nacro K, Liu B, Chai CL.
ACS Med Chem Lett (2011) 2 : 662 -666
PubMed 24900361 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.06 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1173442 AIGIALOMYCIN D 1 6.35
CHEMBL2012392 1 6.24
CHEMBL2012390 1 5.87
CHEMBL2012384 1 5.79
CHEMBL2012386 1 -
CHEMBL2012387 1 -
CHEMBL2012388 1 -
CHEMBL2012389 1 -
CHEMBL2012391 1 -
CHEMBL2012393 1 -
CHEMBL2012394 1 -
CHEMBL2012395 1 -
CHEMBL2012396 1 -
CHEMBL2012385 1 -
CHEMBL2012383 1 -
CHEMBL2012382 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1173442 AIGIALOMYCIN D IC50 = 450.0 nM 6.35
CHEMBL2012392 IC50 = 580.0 nM 6.24
CHEMBL2012390 IC50 = 1350.0 nM 5.87
CHEMBL2012384 IC50 = 1610.0 nM 5.79
CHEMBL2012386 IC50 > 10000.0 nM -
CHEMBL2012387 IC50 > 10000.0 nM -
CHEMBL2012388 IC50 > 10000.0 nM -
CHEMBL2012389 IC50 > 10000.0 nM -
CHEMBL2012391 IC50 > 10000.0 nM -
CHEMBL2012393 IC50 > 10000.0 nM -
CHEMBL2012394 IC50 > 10000.0 nM -
CHEMBL2012395 IC50 > 10000.0 nM -
CHEMBL2012396 IC50 > 10000.0 nM -
CHEMBL2012385 IC50 > 10000.0 nM -
CHEMBL2012383 IC50 > 10000.0 nM -
CHEMBL2012382 IC50 > 10000.0 nM -