Assay Detail
Binding
CHEMBL2015997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of GAL4-fused PPARbeta LBD expressed in HepG2 cells after 20 hrs by luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.64 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153057 | — | — | 1 | 6.19 |
| CHEMBL2011544 | — | — | 1 | 5.31 |
| CHEMBL2011543 | — | — | 1 | 4.65 |
| CHEMBL2011540 | PIPERITOL | — | 1 | 4.47 |
| CHEMBL2011538 | — | — | 1 | 4.32 |
| CHEMBL2011541 | — | — | 1 | 4.31 |
| CHEMBL487611 | PINORESINOL | — | 1 | 4.30 |
| CHEMBL108861 | METHYLEUGENOL | — | 1 | 4.30 |
| CHEMBL2011545 | — | — | 1 | 4.29 |
| CHEMBL2011539 | PLUVIATILOL | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153057 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2011544 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2011543 | — | EC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL2011540 | PIPERITOL | EC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL2011538 | — | EC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL2011541 | — | EC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL487611 | PINORESINOL | EC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL108861 | METHYLEUGENOL | EC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL2011545 | — | EC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL2011539 | PLUVIATILOL | EC50 | = | 53100.0 | nM | 4.28 |