Assay Detail
Functional
CHEMBL2016076
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Cytotoxicity against human K562 cells after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.64 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.37 |
| CHEMBL2012366 | — | — | 1 | 4.38 |
| CHEMBL2012368 | — | — | 1 | 4.36 |
| CHEMBL2012362 | — | — | 1 | 4.34 |
| CHEMBL2012363 | — | — | 1 | 4.27 |
| CHEMBL2012356 | — | — | 1 | 4.11 |
| CHEMBL2012355 | — | — | 1 | - |
| CHEMBL2012357 | — | — | 1 | - |
| CHEMBL2012358 | — | — | 1 | - |
| CHEMBL2012359 | — | — | 1 | - |
| CHEMBL2012360 | — | — | 1 | - |
| CHEMBL2012361 | — | — | 1 | - |
| CHEMBL2012364 | — | — | 1 | - |
| CHEMBL2012365 | — | — | 1 | - |
| CHEMBL2012367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2012366 | — | IC50 | = | 41710.0 | nM | 4.38 |
| CHEMBL2012368 | — | IC50 | = | 43480.0 | nM | 4.36 |
| CHEMBL2012362 | — | IC50 | = | 45360.0 | nM | 4.34 |
| CHEMBL2012363 | — | IC50 | = | 53720.0 | nM | 4.27 |
| CHEMBL2012356 | — | IC50 | = | 77470.0 | nM | 4.11 |
| CHEMBL2012355 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL2012357 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012358 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2012359 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL2012360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012361 | — | IC50 | = | 140300.0 | nM | - |
| CHEMBL2012364 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2012365 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012367 | — | IC50 | > | 100000.0 | nM | - |