Assay Detail
Functional
CHEMBL2016178
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.26 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011863 | — | — | 1 | 6.12 |
| CHEMBL2011861 | — | — | 1 | 6.05 |
| CHEMBL563481 | — | — | 1 | 6.04 |
| CHEMBL551943 | — | — | 1 | 6.02 |
| CHEMBL2011862 | — | — | 1 | 6.01 |
| CHEMBL557057 | — | — | 1 | 5.91 |
| CHEMBL1222953 | — | — | 1 | 5.10 |
| CHEMBL2011864 | — | — | 1 | 5.05 |
| CHEMBL326294 | ISATIN | — | 1 | 4.87 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.82 |
| CHEMBL2011866 | — | — | 1 | 4.16 |
| CHEMBL2011868 | — | — | 1 | 4.15 |
| CHEMBL2011865 | — | — | 1 | 4.12 |
| CHEMBL2011867 | — | — | 1 | - |
| CHEMBL2011869 | — | — | 1 | - |
| CHEMBL564411 | — | — | 1 | - |
| CHEMBL15844 | INDOLE | — | 1 | - |
| CHEMBL1222880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011863 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2011861 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL563481 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL551943 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL2011862 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL557057 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1222953 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2011864 | — | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL326294 | ISATIN | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15070.0 | nM | 4.82 |
| CHEMBL2011866 | — | IC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL2011868 | — | IC50 | = | 71500.0 | nM | 4.15 |
| CHEMBL2011865 | — | IC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL2011867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2011869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL564411 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL15844 | INDOLE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1222880 | — | IC50 | > | 100000.0 | nM | - |