Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2019370

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE by Ellman's method
22
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques.
Chen Y, Fang L, Peng S, Liao H, Lehmann J, Zhang Y.
Bioorg Med Chem Lett (2012) 22 : 3181 -3187
PubMed 22472693 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.58 8.36
Inhibition 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL257126 1 8.36
CHEMBL255304 1 8.12
CHEMBL2018212 2 5.82
CHEMBL2018209 2 5.60
CHEMBL2018205 2 5.32
CHEMBL2018207 2 5.23
CHEMBL2018208 2 5.19
CHEMBL2018210 1 5.17
CHEMBL1523821 1 5.11
CHEMBL2018213 1 5.02
CHEMBL2018211 1 5.01
CHEMBL2018201 1 5.00
CHEMBL2018204 1 4.98
CHEMBL2018200 1 4.91
CHEMBL2018206 1 4.83
CHEMBL2018203 1 -
CHEMBL2018202 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL257126 IC50 = 4.4 nM 8.36
CHEMBL255304 IC50 = 7.6 nM 8.12
CHEMBL2018212 IC50 = 1500.0 nM 5.82
CHEMBL2018209 IC50 = 2500.0 nM 5.60
CHEMBL2018205 IC50 = 4800.0 nM 5.32
CHEMBL2018207 IC50 = 5900.0 nM 5.23
CHEMBL2018208 IC50 = 6500.0 nM 5.19
CHEMBL2018210 IC50 = 6700.0 nM 5.17
CHEMBL1523821 IC50 = 7800.0 nM 5.11
CHEMBL2018213 IC50 = 9500.0 nM 5.02
CHEMBL2018211 IC50 = 9800.0 nM 5.01
CHEMBL2018201 IC50 = 9900.0 nM 5.00
CHEMBL2018204 IC50 = 10500.0 nM 4.98
CHEMBL2018200 IC50 = 12300.0 nM 4.91
CHEMBL2018206 IC50 = 14900.0 nM 4.83
CHEMBL2018203 IC50 > 100000.0 nM -
CHEMBL2018202 IC50 > 100000.0 nM -
CHEMBL2018205 Inhibition - % -
CHEMBL2018207 Inhibition - % -
CHEMBL2018208 Inhibition - % -
CHEMBL2018209 Inhibition - % -
CHEMBL2018212 Inhibition - % -