Assay Detail
Functional
CHEMBL2019580
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Antagonist activity at rat bradykinin B1 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.42 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018873 | — | — | 1 | 7.68 |
| CHEMBL2018868 | — | — | 1 | 7.68 |
| CHEMBL2018867 | — | — | 1 | 7.55 |
| CHEMBL2018872 | — | — | 1 | 7.38 |
| CHEMBL2018874 | — | — | 1 | 7.37 |
| CHEMBL2018871 | — | — | 1 | 7.35 |
| CHEMBL2018869 | — | — | 1 | 7.28 |
| CHEMBL2018870 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018873 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2018868 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2018867 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2018872 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2018874 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2018871 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2018869 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2018870 | — | IC50 | = | 81.0 | nM | 7.09 |