Assay Detail
Functional
CHEMBL2019652
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Antiproliferative activity against human K562 cells after 72 hrs by CellTiter-Glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.66 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 6.97 |
| CHEMBL2017016 | — | — | 1 | 6.94 |
| CHEMBL2017005 | — | — | 1 | 6.90 |
| CHEMBL2017008 | — | — | 1 | 6.88 |
| CHEMBL2017007 | — | — | 1 | 6.80 |
| CHEMBL2017006 | — | — | 1 | 6.74 |
| CHEMBL2017012 | — | — | 1 | 6.69 |
| CHEMBL2017018 | — | — | 1 | 6.42 |
| CHEMBL2017017 | — | — | 1 | 6.25 |
| CHEMBL2017009 | — | — | 1 | 6.03 |
| CHEMBL2017011 | — | — | 1 | - |
| CHEMBL2017010 | — | — | 1 | - |
| CHEMBL2017013 | — | — | 1 | - |
| CHEMBL2017014 | — | — | 1 | - |
| CHEMBL2017015 | — | — | 1 | - |
| CHEMBL2017019 | — | — | 1 | - |
| CHEMBL2017020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL2017016 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2017005 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2017008 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL2017007 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2017006 | — | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL2017012 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL2017018 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2017017 | — | EC50 | = | 559.0 | nM | 6.25 |
| CHEMBL2017009 | — | EC50 | = | 929.0 | nM | 6.03 |
| CHEMBL2017011 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017010 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017013 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017014 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017015 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017019 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2017020 | — | EC50 | > | 1000.0 | nM | - |