Assay Detail
Binding
CHEMBL2019709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D2 catalytic domain (86 to 413) expressed in Escherichia coli BL21 using [3H]-cAMP/[3H]-cGMP after 15 mins by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.49 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 6.34 |
| CHEMBL512578 | MORACIN M | — | 1 | 5.54 |
| CHEMBL2018876 | MORACIN C | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL512578 | MORACIN M | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2018876 | MORACIN C | IC50 | = | 26000.0 | nM | 4.58 |