Assay Detail
Binding
CHEMBL2019764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of guinea pig ENaC expressed in FRT cells by short-circuit current assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | FRT |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212432 | 552-02 FREE BASE | 2.0 | 1 | 8.40 |
| CHEMBL2017991 | — | — | 1 | 7.52 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212432 | 552-02 FREE BASE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017991 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL945 | AMILORIDE | IC50 | = | 540.0 | nM | 6.27 |