Assay Detail
Functional
CHEMBL2019769
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Inhibition of IgE-mediated human LAD2 cell degranulation assessed as beta-hexosaminidase release using p-nitrophenyl-N-acetyl-D-glucosamide as substrate preincubated for 30 mins measured 90 mins after substrate addition by spectrophotometric analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LAD2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazine-based Syk kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.62 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018022 | — | — | 1 | 7.05 |
| CHEMBL2018020 | — | — | 1 | 7.00 |
| CHEMBL2018025 | — | — | 1 | 6.96 |
| CHEMBL2018145 | — | — | 1 | 6.92 |
| CHEMBL2018029 | — | — | 1 | 6.92 |
| CHEMBL2018018 | — | — | 1 | 6.92 |
| CHEMBL2018147 | — | — | 1 | 6.85 |
| CHEMBL2018026 | — | — | 1 | 6.85 |
| CHEMBL2018024 | — | — | 1 | 6.85 |
| CHEMBL2018023 | — | — | 1 | 6.82 |
| CHEMBL2018032 | — | — | 1 | 6.80 |
| CHEMBL2018027 | — | — | 1 | 6.77 |
| CHEMBL2018019 | — | — | 1 | 6.75 |
| CHEMBL2018143 | — | — | 1 | 6.75 |
| CHEMBL2018146 | — | — | 1 | 6.75 |
| CHEMBL2018028 | — | — | 1 | 6.66 |
| CHEMBL2018144 | — | — | 1 | 6.40 |
| CHEMBL2018016 | — | — | 1 | 6.26 |
| CHEMBL2018015 | — | — | 1 | 6.25 |
| CHEMBL2018012 | — | — | 1 | 6.07 |
| CHEMBL2018030 | — | — | 1 | 6.00 |
| CHEMBL2018010 | — | — | 1 | 5.96 |
| CHEMBL2018009 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018022 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018020 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2018025 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2018145 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2018029 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2018018 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2018147 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2018026 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2018024 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2018023 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2018032 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2018027 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2018019 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2018143 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2018146 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2018028 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2018144 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2018016 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2018015 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2018012 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2018030 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2018010 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2018009 | — | IC50 | = | 1960.0 | nM | 5.71 |