Assay Detail
Binding
CHEMBL2019816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-cAMP from human recombinant PDE7B
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 7B (CHEMBL4716) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2019112 | — | — | 1 | 8.10 |
| CHEMBL2019104 | — | — | 1 | 7.77 |
| CHEMBL2019021 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2019112 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2019104 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2019021 | — | IC50 | = | 31.0 | nM | 7.51 |