Assay Detail
Binding
CHEMBL2019838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
26
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.05 | 5.44 |
| Ki | 7 | 5.51 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2019140 | — | — | 2 | 6.04 |
| CHEMBL2019155 | — | — | 1 | 5.76 |
| CHEMBL2019143 | — | — | 2 | 5.70 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 5.65 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.36 |
| CHEMBL2019142 | — | — | 1 | 5.19 |
| CHEMBL2019153 | — | — | 1 | 5.19 |
| CHEMBL2019138 | — | — | 1 | 5.17 |
| CHEMBL2019146 | — | — | 1 | 5.12 |
| CHEMBL2019148 | — | — | 1 | 5.10 |
| CHEMBL2019144 | — | — | 1 | 5.09 |
| CHEMBL2019151 | — | — | 1 | 5.08 |
| CHEMBL2019141 | — | — | 1 | 5.08 |
| CHEMBL2019145 | — | — | 1 | 5.08 |
| CHEMBL2019150 | — | — | 1 | 5.06 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 5.06 |
| CHEMBL2019139 | — | — | 1 | 5.06 |
| CHEMBL2019152 | — | — | 1 | 5.04 |
| CHEMBL2019136 | — | — | 1 | 5.03 |
| CHEMBL2019154 | — | — | 1 | 5.03 |
| CHEMBL294009 | FLAVONOL | — | 1 | 5.03 |
| CHEMBL2019147 | — | — | 1 | 4.86 |
| CHEMBL2019137 | — | — | 1 | 4.44 |
| CHEMBL2019149 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2019140 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL2019155 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL2019143 | — | Ki | = | 2010.0 | nM | 5.70 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL2019140 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL2019143 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL117 | CHRYSIN | Ki | = | 4380.0 | nM | 5.36 |
| CHEMBL2019142 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL2019153 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL2019138 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL2019146 | — | IC50 | = | 7590.0 | nM | 5.12 |
| CHEMBL2019148 | — | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL2019144 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL2019141 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL2019151 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL2019145 | — | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL2019139 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL275638 | FLAVONE | Ki | = | 8710.0 | nM | 5.06 |
| CHEMBL2019150 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL2019152 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL2019154 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL2019136 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL294009 | FLAVONOL | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL2019147 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL2019137 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL2019149 | — | IC50 | = | 36700.0 | nM | 4.43 |