Assay Detail
Binding
CHEMBL2019843
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Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.11 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294009 | FLAVONOL | — | 1 | 5.18 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 5.13 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 5.07 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294009 | FLAVONOL | Ki | = | 6650.0 | nM | 5.18 |
| CHEMBL275638 | FLAVONE | Ki | = | 7330.0 | nM | 5.13 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Ki | = | 8510.0 | nM | 5.07 |
| CHEMBL117 | CHRYSIN | Ki | = | 9070.0 | nM | 5.04 |