Assay Detail
Functional
CHEMBL2020024
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Agonist activity at S1P1 receptor by Tango assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 8.50 | 10.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018176 | — | — | 1 | 10.90 |
| CHEMBL2018320 | — | — | 1 | 10.50 |
| CHEMBL2018321 | — | — | 1 | 10.40 |
| CHEMBL2018319 | — | — | 1 | 10.30 |
| CHEMBL2018322 | — | — | 1 | 10.10 |
| CHEMBL2018178 | — | — | 1 | 9.70 |
| CHEMBL2018177 | — | — | 1 | 9.60 |
| CHEMBL2018306 | — | — | 1 | 9.60 |
| CHEMBL2018324 | — | — | 1 | 9.50 |
| CHEMBL2018179 | — | — | 1 | 9.40 |
| CHEMBL2018318 | — | — | 1 | 9.40 |
| CHEMBL2018307 | — | — | 1 | 8.80 |
| CHEMBL2018174 | — | — | 1 | 8.60 |
| CHEMBL2018309 | — | — | 1 | 8.50 |
| CHEMBL2018316 | — | — | 1 | 8.30 |
| CHEMBL2018327 | — | — | 1 | 8.20 |
| CHEMBL2018326 | — | — | 1 | 7.70 |
| CHEMBL2018330 | — | — | 1 | 7.60 |
| CHEMBL2018317 | — | — | 1 | 7.40 |
| CHEMBL2018308 | — | — | 1 | 7.00 |
| CHEMBL2018325 | — | — | 1 | 6.70 |
| CHEMBL2018175 | — | — | 1 | 6.40 |
| CHEMBL2018312 | — | — | 1 | 6.40 |
| CHEMBL2018310 | — | — | 1 | 5.90 |
| CHEMBL2018313 | — | — | 1 | 5.50 |
| CHEMBL2018315 | — | — | 1 | - |
| CHEMBL2018323 | — | — | 1 | - |
| CHEMBL2018314 | — | — | 1 | - |
| CHEMBL2018311 | — | — | 1 | - |
| CHEMBL2018328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018176 | — | EC50 | = | 0.01259 | nM | 10.90 |
| CHEMBL2018320 | — | EC50 | = | 0.03162 | nM | 10.50 |
| CHEMBL2018321 | — | EC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL2018319 | — | EC50 | = | 0.05012 | nM | 10.30 |
| CHEMBL2018322 | — | EC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL2018178 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL2018177 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL2018306 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL2018324 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL2018179 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL2018318 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL2018307 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL2018174 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL2018309 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL2018316 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2018327 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL2018326 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL2018330 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2018317 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL2018308 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2018325 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2018175 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2018312 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2018310 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL2018313 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL2018315 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2018323 | — | EC50 | = | 0.00631 | nM | - |
| CHEMBL2018314 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2018311 | — | EC50 | > | 3162.28 | nM | - |
| CHEMBL2018328 | — | EC50 | < | 0.01 | nM | - |
| CHEMBL2018329 | — | EC50 | < | 0.01 | nM | - |