Assay Detail
Binding
CHEMBL2020225
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Inhibition of human galactosidase after 30 mins by Kinase-GloTM assay
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.65 | 6.16 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017798 | — | — | 1 | 6.16 |
| CHEMBL2017800 | — | — | 1 | 6.05 |
| CHEMBL2017797 | — | — | 1 | 5.92 |
| CHEMBL2017799 | — | — | 1 | 5.92 |
| CHEMBL1835517 | — | — | 1 | 5.85 |
| CHEMBL2017794 | — | — | 1 | 5.75 |
| CHEMBL2017801 | — | — | 1 | 5.62 |
| CHEMBL493923 | — | — | 1 | 4.92 |
| CHEMBL2017796 | — | — | 1 | 4.65 |
| CHEMBL2017793 | — | — | 1 | - |
| CHEMBL2017795 | — | — | 1 | - |
| CHEMBL1464715 | — | — | 1 | - |
| CHEMBL1835580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017798 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2017800 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2017797 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2017799 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1835517 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2017794 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2017801 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL493923 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2017796 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL2017793 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2017795 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1464715 | — | Inhibition | - | % | - | |
| CHEMBL1835580 | — | Inhibition | - | % | - |