Assay Detail
Binding
CHEMBL2020290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleotide-binding oligomerization domain-containing protein 1 (CHEMBL1293222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 5.66 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1713298 | — | — | 1 | 7.10 |
| CHEMBL1521474 | — | — | 1 | 7.05 |
| CHEMBL1569174 | — | — | 1 | 6.82 |
| CHEMBL1704728 | — | — | 1 | 6.62 |
| CHEMBL1732337 | — | — | 1 | 6.58 |
| CHEMBL1450407 | — | — | 1 | 6.29 |
| CHEMBL1700405 | — | — | 1 | 6.29 |
| CHEMBL1412853 | — | — | 1 | 6.25 |
| CHEMBL1612423 | — | — | 1 | 6.08 |
| CHEMBL1709705 | — | — | 1 | 6.00 |
| CHEMBL1710033 | — | — | 1 | 5.99 |
| CHEMBL1569954 | — | — | 1 | 5.95 |
| CHEMBL1734509 | — | — | 1 | 5.79 |
| CHEMBL1735926 | — | — | 1 | 5.77 |
| CHEMBL1364793 | — | — | 1 | 5.73 |
| CHEMBL1721926 | — | — | 1 | 5.70 |
| CHEMBL1321508 | — | — | 1 | 5.66 |
| CHEMBL1720257 | — | — | 1 | 5.59 |
| CHEMBL1316316 | — | — | 1 | 5.57 |
| CHEMBL1554526 | — | — | 1 | 5.55 |
| CHEMBL1532328 | — | — | 1 | 5.51 |
| CHEMBL1342760 | — | — | 1 | 5.46 |
| CHEMBL1717116 | — | — | 1 | 5.44 |
| CHEMBL1420187 | — | — | 1 | 5.36 |
| CHEMBL1351584 | — | — | 1 | 5.25 |
| CHEMBL1733280 | — | — | 1 | 5.24 |
| CHEMBL1706268 | — | — | 1 | 5.23 |
| CHEMBL1519988 | — | — | 1 | 5.20 |
| CHEMBL1717353 | — | — | 1 | 5.19 |
| CHEMBL1314048 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1713298 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1521474 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1569174 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1704728 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1732337 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1450407 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1700405 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1412853 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1612423 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1709705 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1710033 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1569954 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1734509 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1735926 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1364793 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1721926 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1321508 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1720257 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL1316316 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1554526 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1532328 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL1342760 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL1717116 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL1420187 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL1351584 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1733280 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL1706268 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL1519988 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1717353 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1314048 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1538784 | — | IC50 | = | 10260.0 | nM | 4.99 |
| CHEMBL1728652 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1700889 | — | IC50 | = | 11150.0 | nM | 4.95 |
| CHEMBL1407805 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2018276 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1719980 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL1535050 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1725712 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1699379 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1712058 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1718692 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1729147 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1736791 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1411903 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1728008 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1433326 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2018275 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1363341 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1710228 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1719579 | — | IC50 | > | 20000.0 | nM | - |