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Assay Detail

CHEMBL2020292

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK-293T
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.
Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A, Vicchiarelli M, Su Y, Vasile S, Smith LH, Diaz PW, Reed JC, Roth GP.
ACS Med Chem Lett (2011) 2 : 780 -785
PubMed 22003428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 5.70 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1713298 1 7.52
CHEMBL1569174 1 6.85
CHEMBL1732337 1 6.62
CHEMBL1704728 1 6.43
CHEMBL1612423 1 6.31
CHEMBL1709705 1 6.24
CHEMBL1700405 1 6.19
CHEMBL1710033 1 5.82
CHEMBL1721926 1 5.79
CHEMBL1734509 1 5.74
CHEMBL1569954 1 5.69
CHEMBL1532328 1 5.54
CHEMBL1554526 1 5.50
CHEMBL1735926 1 5.49
CHEMBL1450407 1 5.42
CHEMBL1717116 1 5.37
CHEMBL1733280 1 5.37
CHEMBL1364793 1 5.31
CHEMBL1720257 1 5.24
CHEMBL1420187 1 5.22
CHEMBL1351584 1 5.14
CHEMBL1706268 1 5.06
CHEMBL1728652 1 4.97
CHEMBL1700889 1 4.85
CHEMBL1712058 1 4.82
CHEMBL1736791 1 -
CHEMBL1729147 1 -
CHEMBL1728008 1 -
CHEMBL1720861 1 -
CHEMBL1710228 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1713298 IC50 = 30.0 nM 7.52
CHEMBL1569174 IC50 = 140.0 nM 6.85
CHEMBL1732337 IC50 = 240.0 nM 6.62
CHEMBL1704728 IC50 = 370.0 nM 6.43
CHEMBL1612423 IC50 = 490.0 nM 6.31
CHEMBL1709705 IC50 = 580.0 nM 6.24
CHEMBL1700405 IC50 = 650.0 nM 6.19
CHEMBL1710033 IC50 = 1500.0 nM 5.82
CHEMBL1721926 IC50 = 1630.0 nM 5.79
CHEMBL1734509 IC50 = 1830.0 nM 5.74
CHEMBL1569954 IC50 = 2050.0 nM 5.69
CHEMBL1532328 IC50 = 2880.0 nM 5.54
CHEMBL1554526 IC50 = 3200.0 nM 5.50
CHEMBL1735926 IC50 = 3270.0 nM 5.49
CHEMBL1450407 IC50 = 3850.0 nM 5.42
CHEMBL1717116 IC50 = 4300.0 nM 5.37
CHEMBL1733280 IC50 = 4320.0 nM 5.37
CHEMBL1364793 IC50 = 4920.0 nM 5.31
CHEMBL1720257 IC50 = 5760.0 nM 5.24
CHEMBL1420187 IC50 = 6000.0 nM 5.22
CHEMBL1351584 IC50 = 7260.0 nM 5.14
CHEMBL1706268 IC50 = 8790.0 nM 5.06
CHEMBL1728652 IC50 = 10770.0 nM 4.97
CHEMBL1700889 IC50 = 14100.0 nM 4.85
CHEMBL1712058 IC50 = 15300.0 nM 4.82
CHEMBL1519988 IC50 > 20000.0 nM -
CHEMBL1411903 IC50 > 20000.0 nM -
CHEMBL2018275 IC50 > 20000.0 nM -
CHEMBL1363341 IC50 > 20000.0 nM -
CHEMBL1314048 IC50 > 20000.0 nM -
CHEMBL1535050 IC50 > 20000.0 nM -
CHEMBL1716972 IC50 > 20000.0 nM -
CHEMBL1538784 IC50 > 20000.0 nM -
CHEMBL1699379 IC50 > 20000.0 nM -
CHEMBL1725712 IC50 > 20000.0 nM -
CHEMBL1706542 IC50 > 20000.0 nM -
CHEMBL1730320 IC50 > 20000.0 nM -
CHEMBL1407805 IC50 > 20000.0 nM -
CHEMBL1321508 IC50 > 20000.0 nM -
CHEMBL1316316 IC50 > 20000.0 nM -
CHEMBL1521474 IC50 > 20000.0 nM -
CHEMBL1433326 IC50 > 20000.0 nM -
CHEMBL1412853 IC50 > 20000.0 nM -
CHEMBL2018276 IC50 > 20000.0 nM -
CHEMBL1719579 IC50 > 20000.0 nM -
CHEMBL1710228 IC50 > 20000.0 nM -
CHEMBL1720861 IC50 > 20000.0 nM -
CHEMBL1728008 IC50 > 20000.0 nM -
CHEMBL1729147 IC50 > 20000.0 nM -
CHEMBL1736791 IC50 > 20000.0 nM -