Assay Detail
Binding
CHEMBL2020395
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Inhibition of human recombinant HDAC1 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrs
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.27 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018301 | — | — | 1 | 6.37 |
| CHEMBL2018300 | — | — | 1 | 5.99 |
| CHEMBL2018447 | — | — | 1 | 5.79 |
| CHEMBL2018299 | — | — | 1 | 5.73 |
| CHEMBL2018296 | — | — | 1 | 5.68 |
| CHEMBL2018446 | — | — | 1 | 5.56 |
| CHEMBL2018448 | — | — | 1 | 5.40 |
| CHEMBL2018295 | — | — | 1 | 5.39 |
| CHEMBL2018452 | — | — | 1 | 5.37 |
| CHEMBL2018445 | — | — | 1 | 5.33 |
| CHEMBL2018444 | — | — | 1 | 5.29 |
| CHEMBL2018451 | — | — | 1 | 5.29 |
| CHEMBL2018442 | — | — | 1 | 5.24 |
| CHEMBL2018449 | — | — | 1 | 5.13 |
| CHEMBL2018303 | — | — | 1 | 5.06 |
| CHEMBL2018450 | — | — | 1 | 5.01 |
| CHEMBL2018305 | — | — | 1 | 4.99 |
| CHEMBL2018297 | — | — | 1 | 4.99 |
| CHEMBL2018443 | — | — | 1 | 4.99 |
| CHEMBL2018298 | — | — | 1 | 4.85 |
| CHEMBL2018441 | — | — | 1 | 4.80 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.79 |
| CHEMBL2018304 | — | — | 1 | 4.79 |
| CHEMBL2018294 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018301 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL2018300 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2018447 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL2018299 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL2018296 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL2018446 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL2018448 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL2018295 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL2018452 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL2018445 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL2018444 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL2018451 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL2018442 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL2018449 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL2018303 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL2018450 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2018305 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2018297 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2018443 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2018298 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL2018441 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL2018304 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL2018294 | — | IC50 | = | 22100.0 | nM | 4.66 |