Assay Detail
Binding
CHEMBL2020396
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Inhibition of human recombinant HDAC6 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrs
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.51 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018447 | — | — | 1 | 9.34 |
| CHEMBL2018446 | — | — | 1 | 9.23 |
| CHEMBL2018301 | — | — | 1 | 9.15 |
| CHEMBL2018448 | — | — | 1 | 9.10 |
| CHEMBL2018452 | — | — | 1 | 9.06 |
| CHEMBL2018442 | — | — | 1 | 9.01 |
| CHEMBL2018300 | — | — | 1 | 8.99 |
| CHEMBL2018451 | — | — | 1 | 8.85 |
| CHEMBL2018443 | — | — | 1 | 8.84 |
| CHEMBL2018303 | — | — | 1 | 8.65 |
| CHEMBL2018450 | — | — | 1 | 8.60 |
| CHEMBL2018444 | — | — | 1 | 8.53 |
| CHEMBL2018305 | — | — | 1 | 8.52 |
| CHEMBL2018445 | — | — | 1 | 8.52 |
| CHEMBL2018299 | — | — | 1 | 8.51 |
| CHEMBL2018449 | — | — | 1 | 8.39 |
| CHEMBL2018296 | — | — | 1 | 8.31 |
| CHEMBL2018304 | — | — | 1 | 8.18 |
| CHEMBL2018441 | — | — | 1 | 8.05 |
| CHEMBL2018295 | — | — | 1 | 7.94 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL2018298 | — | — | 1 | 7.65 |
| CHEMBL2018294 | — | — | 1 | 7.46 |
| CHEMBL2018297 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018447 | — | IC50 | = | 0.459 | nM | 9.34 |
| CHEMBL2018446 | — | IC50 | = | 0.582 | nM | 9.23 |
| CHEMBL2018301 | — | IC50 | = | 0.704 | nM | 9.15 |
| CHEMBL2018448 | — | IC50 | = | 0.799 | nM | 9.10 |
| CHEMBL2018452 | — | IC50 | = | 0.872 | nM | 9.06 |
| CHEMBL2018442 | — | IC50 | = | 0.972 | nM | 9.01 |
| CHEMBL2018300 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL2018451 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2018443 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL2018303 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL2018450 | — | IC50 | = | 2.49 | nM | 8.60 |
| CHEMBL2018444 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL2018305 | — | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL2018445 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL2018299 | — | IC50 | = | 3.06 | nM | 8.51 |
| CHEMBL2018449 | — | IC50 | = | 4.06 | nM | 8.39 |
| CHEMBL2018296 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2018304 | — | IC50 | = | 6.56 | nM | 8.18 |
| CHEMBL2018441 | — | IC50 | = | 8.96 | nM | 8.05 |
| CHEMBL2018295 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2018298 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2018294 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL2018297 | — | IC50 | = | 38.4 | nM | 7.42 |