Assay Detail
Binding
CHEMBL2020643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 5.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018886 | — | — | 1 | 8.70 |
| CHEMBL2018884 | — | — | 1 | 8.40 |
| CHEMBL2018885 | — | — | 1 | 8.22 |
| CHEMBL2018882 | — | — | 1 | 8.22 |
| CHEMBL1761942 | — | — | 1 | 7.52 |
| CHEMBL2018883 | — | — | 1 | 7.40 |
| CHEMBL2018881 | — | — | 1 | 7.40 |
| CHEMBL1761939 | — | — | 1 | 7.40 |
| CHEMBL1761937 | — | — | 1 | 7.30 |
| CHEMBL1277162 | — | — | 1 | 7.22 |
| CHEMBL179603 | — | — | 1 | 7.16 |
| CHEMBL1761938 | — | — | 1 | 7.05 |
| CHEMBL1761936 | — | — | 1 | 6.40 |
| CHEMBL2018752 | — | — | 1 | 6.30 |
| CHEMBL1277254 | — | — | 1 | 6.22 |
| CHEMBL1278149 | — | — | 1 | 6.22 |
| CHEMBL1761932 | — | — | 1 | 6.22 |
| CHEMBL1277253 | — | — | 1 | 6.22 |
| CHEMBL2018756 | — | — | 1 | 6.19 |
| CHEMBL1761930 | — | — | 1 | 6.16 |
| CHEMBL328106 | — | — | 1 | 6.10 |
| CHEMBL2018757 | — | — | 1 | 6.07 |
| CHEMBL2018755 | — | — | 1 | 6.07 |
| CHEMBL2018766 | — | — | 1 | 6.00 |
| CHEMBL205089 | — | — | 1 | 6.00 |
| CHEMBL1277620 | — | — | 1 | 5.78 |
| CHEMBL2018753 | — | — | 1 | 5.48 |
| CHEMBL2018769 | — | — | 1 | 5.47 |
| CHEMBL2018771 | — | — | 1 | 5.43 |
| CHEMBL2018746 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018886 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018884 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018882 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2018885 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1761942 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2018883 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2018881 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761939 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761937 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1277162 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL179603 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1761938 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1761936 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2018752 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1277253 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1278149 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1761932 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1277254 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2018756 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1761930 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL328106 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2018757 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2018755 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2018766 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL205089 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1277620 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL2018753 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2018769 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL2018771 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2018746 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1761944 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2016600 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2018777 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2018754 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2018750 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL2018748 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2018751 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL1761933 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2018768 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2018759 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL2018758 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2018775 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL301018 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2018760 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL1761931 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2018879 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1761929 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2018763 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2018764 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2018767 | — | IC50 | = | 6450.0 | nM | 5.19 |