Assay Detail
Functional
CHEMBL2020644
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Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.07 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301018 | — | — | 1 | 5.19 |
| CHEMBL1761944 | — | — | 1 | 5.03 |
| CHEMBL2018881 | — | — | 1 | 5.03 |
| CHEMBL2018752 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301018 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1761944 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2018881 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2018752 | — | IC50 | = | 9800.0 | nM | 5.01 |