Assay Detail
Functional
CHEMBL2020645
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.29 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018777 | — | — | 1 | 5.60 |
| CHEMBL2018767 | — | — | 1 | 5.59 |
| CHEMBL2018776 | — | — | 1 | 5.59 |
| CHEMBL2018775 | — | — | 1 | 5.44 |
| CHEMBL2018769 | — | — | 1 | 5.26 |
| CHEMBL301018 | — | — | 1 | 5.24 |
| CHEMBL1761933 | — | — | 1 | 5.24 |
| CHEMBL2018879 | — | — | 1 | 5.24 |
| CHEMBL2018765 | — | — | 1 | 5.23 |
| CHEMBL1761944 | — | — | 1 | 5.21 |
| CHEMBL2018878 | — | — | 1 | 5.21 |
| CHEMBL2018766 | — | — | 1 | 5.12 |
| CHEMBL2018882 | — | — | 1 | 5.04 |
| CHEMBL2018881 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018777 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2018767 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL2018776 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL2018775 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2018769 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL301018 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1761933 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2018879 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2018765 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1761944 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2018878 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL2018766 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2018882 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2018881 | — | IC50 | = | 9900.0 | nM | 5.00 |