Assay Detail
Binding
CHEMBL2020770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.01 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017348 | — | — | 1 | 8.70 |
| CHEMBL2017324 | — | — | 1 | 8.70 |
| CHEMBL2017323 | — | — | 1 | 8.52 |
| CHEMBL2017346 | — | — | 1 | 8.52 |
| CHEMBL2017322 | — | — | 1 | 8.40 |
| CHEMBL2017347 | — | — | 1 | 8.40 |
| CHEMBL2017336 | — | — | 1 | 8.40 |
| CHEMBL2017352 | — | — | 1 | 8.40 |
| CHEMBL2017328 | — | — | 1 | 8.40 |
| CHEMBL2017359 | — | — | 1 | 8.30 |
| CHEMBL2017360 | — | — | 1 | 8.30 |
| CHEMBL2017343 | — | — | 1 | 8.30 |
| CHEMBL2017356 | — | — | 1 | 8.22 |
| CHEMBL2017339 | — | — | 1 | 8.22 |
| CHEMBL2017326 | — | — | 1 | 8.15 |
| CHEMBL2017350 | — | — | 1 | 8.15 |
| CHEMBL2017329 | — | — | 1 | 8.10 |
| CHEMBL2017332 | — | — | 1 | 8.10 |
| CHEMBL2017344 | — | — | 1 | 8.05 |
| CHEMBL2017349 | — | — | 1 | 8.05 |
| CHEMBL2017342 | — | — | 1 | 8.05 |
| CHEMBL2017355 | — | — | 1 | 8.00 |
| CHEMBL2017351 | — | — | 1 | 7.96 |
| CHEMBL2017331 | — | — | 1 | 7.92 |
| CHEMBL2017341 | — | — | 1 | 7.85 |
| CHEMBL2017340 | — | — | 1 | 7.85 |
| CHEMBL2017330 | — | — | 1 | 7.85 |
| CHEMBL2017361 | — | — | 1 | 7.82 |
| CHEMBL2017334 | — | — | 1 | 7.82 |
| CHEMBL2017353 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017348 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017324 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017346 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2017323 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2017322 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017347 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017336 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017352 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017328 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017360 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017343 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017359 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017356 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017339 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017350 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2017326 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2017329 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2017332 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2017342 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017344 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017349 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017355 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017351 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2017331 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2017341 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2017340 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2017330 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2017361 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2017334 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2017353 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2017327 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2017354 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2017337 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2017357 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2017325 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2017335 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2017333 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2017345 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2017358 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2017338 | — | IC50 | = | 91.0 | nM | 7.04 |