Assay Detail
Binding
CHEMBL2020773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CK2 (alphaalpha-betabeta) holoenzyme using RRRDDDSDDD as substrate and 15 uM ATP by radiometric assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017356 | — | — | 1 | 8.70 |
| CHEMBL2017324 | — | — | 1 | 8.40 |
| CHEMBL2017352 | — | — | 1 | 8.30 |
| CHEMBL2017346 | — | — | 1 | 8.15 |
| CHEMBL2017347 | — | — | 1 | 8.15 |
| CHEMBL2017323 | — | — | 1 | 8.05 |
| CHEMBL2017341 | — | — | 1 | 8.00 |
| CHEMBL2017322 | — | — | 1 | 8.00 |
| CHEMBL2017325 | — | — | 1 | 8.00 |
| CHEMBL2017351 | — | — | 1 | 7.96 |
| CHEMBL2017348 | — | — | 1 | 7.96 |
| CHEMBL2017339 | — | — | 1 | 7.82 |
| CHEMBL2017343 | — | — | 1 | 7.77 |
| CHEMBL2017326 | — | — | 1 | 7.70 |
| CHEMBL2017332 | — | — | 1 | 7.68 |
| CHEMBL2017328 | — | — | 1 | 7.68 |
| CHEMBL2017359 | — | — | 1 | 7.66 |
| CHEMBL2017354 | — | — | 1 | 7.62 |
| CHEMBL2017361 | — | — | 1 | 7.58 |
| CHEMBL2017327 | — | — | 1 | 7.52 |
| CHEMBL2017340 | — | — | 1 | 7.48 |
| CHEMBL2017333 | — | — | 1 | 7.46 |
| CHEMBL2017329 | — | — | 1 | 7.41 |
| CHEMBL2017360 | — | — | 1 | 7.32 |
| CHEMBL2017336 | — | — | 1 | 7.32 |
| CHEMBL2017342 | — | — | 1 | 7.28 |
| CHEMBL2017334 | — | — | 1 | 7.21 |
| CHEMBL2017337 | — | — | 1 | 7.12 |
| CHEMBL2017345 | — | — | 1 | 7.12 |
| CHEMBL2017349 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017356 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017324 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017352 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017346 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2017347 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2017323 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017341 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017322 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017325 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017351 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2017348 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2017339 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2017343 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2017326 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2017328 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2017332 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2017359 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2017354 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2017361 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2017327 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2017340 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2017333 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2017329 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2017360 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2017336 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2017342 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2017334 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2017337 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2017345 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2017349 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2017350 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2017331 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2017330 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2017355 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL2017335 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL2017353 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL2017357 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2017358 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2017344 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2017338 | — | IC50 | = | 216.0 | nM | 6.67 |