Assay Detail
Functional
CHEMBL2020777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells after 48 hrs by alamar blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.26 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017323 | — | — | 1 | 5.44 |
| CHEMBL2017324 | — | — | 1 | 5.44 |
| CHEMBL2017348 | — | — | 1 | 5.32 |
| CHEMBL2017333 | — | — | 1 | 5.27 |
| CHEMBL2017322 | — | — | 1 | 5.21 |
| CHEMBL2017356 | — | — | 1 | 5.17 |
| CHEMBL2017352 | — | — | 1 | 5.14 |
| CHEMBL2017332 | — | — | 1 | 5.09 |
| CHEMBL2017326 | — | — | 1 | - |
| CHEMBL2017328 | — | — | 1 | - |
| CHEMBL2017329 | — | — | 1 | - |
| CHEMBL2017346 | — | — | 1 | - |
| CHEMBL2017347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017323 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2017324 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2017348 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2017333 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2017322 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2017356 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2017352 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2017332 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2017326 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2017328 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2017329 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2017346 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2017347 | — | EC50 | > | 10000.0 | nM | - |