Assay Detail
Functional
CHEMBL2020778
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by alamar blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.31 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017328 | — | — | 1 | 5.89 |
| CHEMBL2017329 | — | — | 1 | 5.70 |
| CHEMBL2017323 | — | — | 1 | 5.58 |
| CHEMBL2017346 | — | — | 1 | 5.58 |
| CHEMBL2017333 | — | — | 1 | 5.51 |
| CHEMBL2017348 | — | — | 1 | 5.34 |
| CHEMBL2017326 | — | — | 1 | 5.31 |
| CHEMBL2017347 | — | — | 1 | 5.18 |
| CHEMBL2017324 | — | — | 1 | 5.15 |
| CHEMBL2017352 | — | — | 1 | 5.13 |
| CHEMBL2017322 | — | — | 1 | 5.11 |
| CHEMBL2017356 | — | — | 1 | 5.03 |
| CHEMBL2017332 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017328 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2017329 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2017323 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2017346 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2017333 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2017348 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2017326 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2017347 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2017324 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2017352 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2017322 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2017356 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2017332 | — | EC50 | = | 28400.0 | nM | 4.55 |