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Assay Detail

CHEMBL2020838

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of plasmin by dixon plot method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A new strategy for the development of highly potent and selective plasmin inhibitors.
Saupe SM, Steinmetzer T.
J Med Chem (2012) 55 : 1171 -1180
PubMed 22276953 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.05 9.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2016873 1 9.11
CHEMBL2016865 1 9.09
CHEMBL2016870 1 8.96
CHEMBL2016872 1 8.96
CHEMBL2016874 1 8.66
CHEMBL2016871 1 8.60
CHEMBL2016877 1 8.51
CHEMBL2016869 1 8.39
CHEMBL2016868 1 8.16
CHEMBL2016867 1 8.05
CHEMBL2016875 1 8.05
CHEMBL2016864 1 8.03
CHEMBL2016866 1 6.37
CHEMBL2016876 1 6.28
CHEMBL2016878 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2016873 Ki = 0.77 nM 9.11
CHEMBL2016865 Ki = 0.81 nM 9.09
CHEMBL2016870 Ki = 1.1 nM 8.96
CHEMBL2016872 Ki = 1.1 nM 8.96
CHEMBL2016874 Ki = 2.2 nM 8.66
CHEMBL2016871 Ki = 2.5 nM 8.60
CHEMBL2016877 Ki = 3.08 nM 8.51
CHEMBL2016869 Ki = 4.1 nM 8.39
CHEMBL2016868 Ki = 6.9 nM 8.16
CHEMBL2016867 Ki = 9.0 nM 8.05
CHEMBL2016875 Ki = 8.9 nM 8.05
CHEMBL2016864 Ki = 9.4 nM 8.03
CHEMBL2016866 Ki = 431.0 nM 6.37
CHEMBL2016876 Ki = 530.0 nM 6.28
CHEMBL2016878 Ki = 2700.0 nM 5.57